The use and the action of Epipen : video
- What is the use of Epipen?
- What are the symptoms of anaphylaxis?
- What is the role of Epipen in the body?
The blood groups : video
- What are the groups of red blood cells?
- What is the benefit from knowing the blood type?
- Why does type (O) is a universal donner?
Understanding of myocardial infarction : video
- How does the thrombus occur in heart artery?
- How does the Myocardial Infarction occur?
- What are the symptoms of myocardial infarction?
Understanding of lymphatic system : video
- What is the function of the lymph system?
- How does the lymph tissue return to the circulatory system?
- What are the contents of the lymph node?
Lipid lowering agents : rapid review
- Introduction.
- Statins.
- Fibrates.
- Nicotinic acid.
- Cholesteramine and colestipol.
- Omega - 3.
- Probucol.
Introduction:-
Triglycerides:
- Main constituent of vegetable oil & animal fat.
- High triglycerides (normal range 150mg/dl) lead to atherogenesis.
- It's used by the body as energy store except for the brain.
Cholesterol:
- Used as building block of biological membrane & precursor for most steroid hormones.
- Rate limiting enzyme in cholesterol synthesis in the liver is HMGCA reductase enzyme.
- Liver use cholesterol in the synthesis of bile acids & VLDL.
- 85% of the blood cholesterol is produced in the body.
Main Lipid lowering agents
1- Statins (atorvastatin, fluvastatin, rosuvastatin, simvastatin).
- Mechanism of action: statins are inhibitors of HMGcoA reductase (hydroxyl methyl glutaryl coA enzyme) so they inhibit cholesterol synthesis. In addition to that, they increase expression of LDL receptor.
- Statins may occur naturally in some foods like mushroom & red yeast rice.
- Cholesterol synthesis appears to occur mostly at night so short acting statin e.g. simvastatin (zocor) must be taken at night to maximize its effect but long acting statin e.g. atorvastatin (lipitor) may be taken at any time.
- The most potent statin [atorvastatin, rosuvastatin (crestor)].
- The least potent statin {fluvastatin (lescol)}.
- The result of statin therapy appears rapidly may be after one week.
- Side effects: rarely [skeletal musculature damage, liver enzymes become high].
2-Fibrates (bezofibrate, etofibrate, gemfibrozil, fenofibrate)
- Used as accessory therapy in many forms of hypercholesterolemia usually in combination with statins specially fenofibrate (tricor) and gemfibrozil (lopid600) because using of them with statin will increase muscle toxicity by decreasing statin metabolisms.
- It's indicated solely for patient no tolerant to statin.
- Mechanism of action:- activate PPAR (peroxisome proliferators activated receptor) which induce transcription of number of genes that facilitate lipid metabolism, also it decrease VLDL and increase HDL.
- When triglycerides increase more than 1000mg/dl lead to pancreatitis with abdominal pain & as fibrates decrease triglycerides they decrease pancreatitis.
- Side effects: high risk of gallstones (use over several years) myopathy, myalgia and rhabdomyolysis.
- Usage of statins with fibrates may increase the likelihood of rhabdomyolysis & liver failure.
3-Nicotinic acid [niacin or vit b3 & its
derivatives]
- Mechanism of action: stimulate endothelial lipoprotein lipase so decrease triglyceride.
- At the first of the therapy PG mediated vasodilatation occur leading to 2 side effects {flushing and hypotension}.
- To overcome these 2 side effects 325mg of ASA can be taken 30 min prior to nicotinic acid (niaspan). also the extended release dosage decrease flushing.
- Flushing which occurs as side effect of nicotinic acid may make nicotinic acid to be used for male impotence.
- Deficiency of vit b3 may lead to pellagra disease (3 diseases: diarrhea, dementia & dermatitis).
4-Cholesteramine & colestipol:
- They are bile acid sequestrants which bind bile acid in the GIT & prevent its reabsorbtion. As bile acid decrease, liver convert cholesterol into bile acid so cholesterol decrease.
- Side effects of cholesteran (questran) & colestipol (colestid) :
- Diverse GIT disturbance (constipation, diarrhea).
- Decrease the absorption of lipid soluble vitamins (A, D, E, and K).
- Decrease absorption of vit K antagonist, digitoxin and diuretics.
- If used with any other drug (statin or other) must be taken 1hour after the drug or the other drug taken 4 hour after it as they bind statin in the intestin & decrease its absorption.
5-Omega-3 (polyunsaturated fatty acid [eicosapentanoate-docosahexapentaneoate]
- Decrease each of (triglycerides, synthesis of VLDL lipoprotein B and remnant particles).
- Although it doesn't decrease LDL or total cholesterol, with increasing some dietary supplements as fish-leafy green vegetables-nuts-hummus-eggs- linseed-flaxseed this decrease Congestive heart disease.
6-Probucol:
- Decrease HDL more than LDL nonetheless decreases atherogenesis and that may be due to decreasing LDL oxidation.
- Prepared by: Dr. Mustafa Abdel Tawab (pharmacist).
- Resources: - Color atlas of pharmacology. - Drugs.com. - Master of Egyptian drugs. - Wikipedia. - Master of Saudi drugs.
- Copyrights: All rights are reserved for pharmacist development group 2009 - 2011.
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Understanding of hypertention and its effects on the body : video
- What is the relation between blood pressure and the blood flow & the heart rate?
- What is the effects of high blood pressure on the following : heart, blood vessels, kidney, eye & brain?
The parts of nephron and the diuretics action : video
- What is the function of the following : proximal convoluted tubule, loop of henle, distal convoluted tubule & collecting tubule ?
- Where do the following diuretics act and what is the mechanism of action of them : carbonic anhydrase, thiazides, loop diuretics & sodium channel blockers ?
- What is the following processes occur : filtration, reabsorption & collection ?
