Mebendazole (Vermox) : drug card
Drug name
|
# Mebendazole.
|
Brand name
|
# Vermox.
|
Class of drug
|
# Anthelmintic.
|
Indications
|
# Anthelmintic (Pinworms,
Roundworms, hookworms,
whipworms).
# Capillariasis.
|
Mechanism of action
|
# Inhibits uptake of glucose and other
nutrients
by
parasitic helminths.
|
route / Dosage form
|
# Route : Oral only.
# Dosage form : Sus:- 20mg/ml,Tab:- 100mg.
|
Dose
|
# Pinworms
* Adults, children >12 years: 100 mg as single dose. Repeat
in 2 weeks if infection persists. Treat other family
members.
# Roundworms, hookworms, whipworms
* 100 mg b.i.d. for 3 days. Repeat dose
in 3–4 weeks.
# Capillariasis
* Pediatric: 200 mg b.i.d. for 20 days.
Its use in children <2 years is considered a relative contraindication.
|
Pregnancy / Lactation
|
# Pregnancy: Category C.
# Lactation: Probably present in minute amounts in breast milk. May continue breastfeeding.
|
Adverse reactions
|
# Common: diarrhea,
abdominal pain, nausea,
vomiting.
# Serious: bone marrow suppression, hepatitis,
hypersensitivity reactions.
|
Important interactions
|
# Drugs that decrease effects/
toxicity
of mebendazole: phenytoin, carbamazepine, cimetidine.
|
Contraindications / precautions
|
# Use with caution in patients with liver disease, ulcerative
colitis, Crohn’s ileitis.
|
Other notes
|
# Food: Take with food.
|
Practical notes
|
# Avoid driving and other activities requiring
mental alertness or that are potentially dangerous until response to drug is
known.
# Patient and family members should shower
frequently if
possible.
# Keep hands away from mouth.
# Keep fingernails short and clean.
# Do not shake bedding as this could result in
airborne spread of ova.
# Counsel patient’s family members to check for
worm infestation and treat accordingly.
# Disinfect toilet daily; wash all fruits and
vegetables; cook all meats and vegetables thoroughly.
# Wear gloves when preparing food.
# Patient and family members should be taught how to avoid
reinfestation with these worms. The
following measures
should be undertaken to avoid reinfection:
(1) perianal area should be washed
thoroughly;
(2) hands and fingernails should be cleaned
before meals and after defecation;
(3) undergarments and bedclothes should be
changed daily.
# Mebendazole is the drug of choice for whipworm;
it can produce up to 70% cure with a single treatment. The cure rate for roundworms,
pinworms, and hookworms is 90–100%. The criterion for cure is negative
perianal swabs for 7 days.
# For those treated for hookworm and whipworm: it
may be necessary to take an iron supplement every day and for 6 months following
treatment if anemia is present.
|
Generic names
|
#
Egypt :Antiver,Vermin,Anthelmin,Mebamox,Verm1.
#
KSA :- Vermox,Bendazole,Parazole,wormazole.
|
- Prepared by: Dr. Mohamed Abdel Rahman. (pharmacist).
- Resources: - Handbook of clinical drug data, 10th edition. - Clinician's
handbook of prescription drugs . - Physicians' Drug manual 2005 Edition . - Master of Egyptian drugs. - Master of Saudi drugs.
- Copyrights: All rights are reserved for pharmacist development group 2009 - 2011.
|
Posted by Unknown
on 12/07/2010.
Filed under
drug cards,
drugs,
GIT
.
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