Acetylcysteine ( mucomyst ) : drug card
Drug name
|
#
Acetylcysteine.
|
Brand name
|
#
Mucomyst.
|
Class of drug
|
#
Mucolytic agent. # antidote.
|
Indications
|
# Mucolytic
agent in Bronchial disorders, chronic bronchitis, asthma, emphysema, pulmonary
complications of surgery.
# Antidote for acetaminophen poisoning.
|
Mechanism of action
|
# As mucolytic agent: disrupts
disulfide bonds in mucoproteins thereby lowering viscosity of mucus.
#
As antidote for
acetaminophen poisoning: complexes with hepatotoxic free radial metabolite
of acetaminophen and inactivates it.
|
route / Dosage form
|
# Route
: Oral, inhalation,
IV.
# Dosage form : Soln: 10, 20%
|
Dose
|
# Bronchial disorders, chronic
bronchitis, asthma, emphysema, pulmonary complications of surgery :-
* Adults:
6–10 mL of 10% solution, q2–3 hours by nebulizer.
* Children:
3–5 mL of 10% solution, q2–3 hours by nebulizer.
* Infants:
2–4 mL of 10% solution, t.i.d. to q.i.d., IV.
* Alternate:
20% solution may be given in half of above volumes.
# Antidote for acetaminophen
poisoning
* Adults,
children: Initially 140 mg/kg, then 70 mg/kg q4h orally x 17 doses. All 17
doses must be given, even if acetaminophen
levels have declined to non-toxic range. If patient has emesis with 1
hour of dose, repeat dose immediately.
|
Pregnancy / Lactation
|
# Pregnancy: Category B.
#
Lactation: No data available. Best to avoid.
|
Adverse reactions
|
# Common: vomiting,
olfactory disturbance.
# Serious: bronchospasm (especially
in asthmatics), hypotension.
|
Important interactions
|
#
None
|
Contraindications / precautions
|
# As inhaled drug: may induce
bronchospasm. If this occurs, administer bronchodilator; suction bronchial
secretions if they develop after inhalation.
# Elderly: May have reduced cough
reflex and therefore reduced ability to clear airway of liquefied mucus. May
need concomitant suction.
# For patient with asthma or
hyperactive airway disease, a bronchodilator should be administered before
acetylcysteine.
|
Other notes
|
#
To be given before meals and just before
bedtime for asthma.
# As antidote
for acetaminophen poisoning: Administer as quickly
as possible. Most useful if given within 12 hours of ingestion of acetaminophen.
|
Practical notes
|
# Rinse mouth out and wash face
after treatment to remove adhering drug.
|
Generic names
|
#
Egypt :- Acetylcistein , ACC
, Mucomyst .
#
KSA :- ACC, Acetylcistein.
|
- Prepared by: Dr. Mohamed Abdel Rahman (pharmacist).
- Resources: - Handbook of clinical drug data. 10th edition. - Clinician's handbook of prescription drugs. - Master of Egyptian drugs. - physicians' Drug manual 2005 edition. - Master of Saudi drugs.
- Copyrights: All rights are reserved for pharmacist development group 2009 - 2011.
|
Posted by Unknown
on 10/04/2010.
Filed under
drug cards,
drugs,
featured,
respiratory system,
toxocology
.
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